Register now

To access the site, please provide the required information to verify that you are a Canadian healthcare professional and create an account. Once validated, this account can be used to log in to all myAstraZeneca websites for Canadian healthcare professionals. Please use the first and last name registered with your professional college.

Login/Register
EN FR

Welcome to IMFINZI.ca

A resource for Canadian healthcare professionals

Please select an indication:

uNSCLC—Unresectable non-small cell lung cancer

Locally Advanced, Unresectable, Stage III Non-Small Cell Lung Cancer1 

PrIMFINZI® (durvalumab) is indicated for the treatment of patients with locally advanced, unresectable, Stage III non-small cell lung cancer (NSCLC) whose disease has not progressed following platinum-based chemoradiation therapy.

Learn more

ES-SCLC—Extensive-stage small cell lung cancer

Extensive-Stage Small Cell Lung Cancer1

IMFINZI in combination with etoposide and either carboplatin or cisplatin is indicated for the first-line treatment of adult patients with extensive-stage small cell lung cancer (ES-SCLC).

Learn more

BTC—Biliary tract cancer

Locally Advanced or Metastatic Biliary Tract Cancer1

IMFINZI in combination with gemcitabine-based chemotherapy is indicated for the treatment of patients with locally advanced or metastatic biliary tract cancer (BTC).

Learn more

uHCC—Unresectable Hepatocellular carcinoma

Unresectable Hepatocellular Carcinoma1

IMFINZI in combination with tremelimumab is indicated for the first-line treatment of adult patients with unresectable hepatocellular carcinoma (uHCC) who require systemic therapy.

  • When using IMFINZI in combination with tremelimumab, consult the Product Monograph for IMJUDO (tremelimumab) for further information on this drug.

IMFINZI, as monotherapy, is indicated for the first-line treatment of adult patients with uHCC who require systemic therapy.

Learn more

MIBC—Muscle invasive bladder cancer

Resectable Muscle Invasive Bladder Cancer1

IMFINZI is indicated for the treatment of patients with resectable muscle invasive bladder cancer (MIBC) in combination with gemcitabine and cisplatin as neoadjuvant treatment, followed by adjuvant IMFINZI monotherapy treatment after radical cystectomy.

Learn more

GC/GEJC—Gastric or gastroesophageal junction cancer

Resectable Gastric and Gastroesophageal Junction Adenocarcinoma1

IMFINZI in combination with fluorouracil, leucovorin, oxaliplatin, and docetaxel (FLOT) chemotherapy as neoadjuvant and adjuvant treatment, followed by adjuvant IMFINZI monotherapy, is indicated for the treatment of adult patients with resectable gastric or gastroesophageal junction adenocarcinoma (GC/GEJC) (Stage II to IVA).

Learn more

Back to top

IMFINZI (durvalumab)

Indications and clinical use:

PrIMFINZI® (durvalumab) is indicated for:

  • Treatment of patients with locally advanced or metastatic urothelial carcinoma who:
    • Have disease progression during or following platinum-containing chemotherapy
    • Have disease progression within 12 months of neoadjuvant or adjuvant treatment with platinum-containing chemotherapy

has been issued market authorization with conditions, pending the results of trials to verify its clinical benefit. Patients should be advised of the nature of the authorization. For further information for IMFINZI please refer to Health Canada’s Notice of Compliance with conditions - drug products web site: https://www.canada.ca/en/health-canada/services/drugs-health-products/drug-products/notice-compliance/conditions.html.

PrIMFINZI® (durvalumab), indicated for:

  • Treatment of patients with resectable muscle invasive bladder cancer (MIBC) in combination with gemcitabine and cisplatin as neoadjuvant treatment, followed by adjuvant IMFINZI monotherapy treatment after radical cystectomy
  • Treatment of patients with locally advanced, unresectable, Stage III non-small cell lung cancer (NSCLC) whose disease has not progressed following platinum-based chemoradiation therapy
  • First-line treatment of adult patients with metastatic NSCLC with no sensitizing epidermal growth factor receptor (EGFR) mutations or anaplastic lymphoma kinase (ALK) genomic tumour aberrations in combination with tremelimumab and platinum-based chemotherapy
  • Treatment, as monotherapy, of adult patients with limited-stage small cell lung cancer (LSSCLC) whose disease has not progressed following platinum-based chemoradiation therapy (CRT)
  • First-line treatment of adult patients with extensive-stage small cell lung cancer (ES-SCLC) in combination with etoposide and either carboplatin or cisplatin
  • Treatment of patients with locally advanced or metastatic biliary tract cancer (BTC) in combination with gemcitabine-based chemotherapy
  • First-line treatment of adult patients with unresectable hepatocellular carcinoma (uHCC) who require systemic therapy, in combination with tremelimumab
  • First-line treatment of adult patients with uHCC who require systemic therapy, as monotherapy 
  • In combination with carboplatin and paclitaxel for the first-line treatment of adult patients with primary advanced or recurrent mismatch repair deficient (dMMR) endometrial cancer who are candidates for systemic therapy, followed by maintenance treatment with IMFINZI as monotherapy
  • In combination with fluorouracil, leucovorin, oxaliplatin, and docetaxel (FLOT) chemotherapy as neoadjuvant and adjuvant treatment, followed by adjuvant IMFINZI monotherapy, for the treatment of adult patients with resectable gastric or gastroesophageal junction adenocarcinoma (GC/GEJC) (Stage II to IVA)

has been issued market authorization without conditions.

The safety and efficacy of IMFINZI in patients younger than 18 years of age have not been established. Therefore, Health Canada has not authorized an indications for pediatric use. 

No overall differences in safety or efficacy were reported between elderly patients (≥65 years of age) and younger patients (<65 years of age). 

Contraindications:

IMFINZI is contraindicated in patients who are hypersensitive to durvalumab or to any ingredient in the formulation, including any non-medicinal ingredient, or component of the container.

Most serious warnings and precautions:

Immune-mediated adverse reactions: IMFINZI as monotherapy or in combination with other products can cause severe and fatal immune-mediated adverse reactions, including enterocolitis, intestinal perforation, hepatitis, dermatitis, Stevens-Johnson syndrome, endocrinopathy, pneumonitis, interstitial lung disease, myocarditis, neuropathy, encephalitis, myasthenia gravis, as well as toxicities in other organ systems. Immune-mediated adverse reactions have occurred at higher frequencies when IMFINZI is administered as a combination therapy with tremelimumab compared with IMFINZI as monotherapy.

Other relevant warnings and precautions:

  • Administer under the supervision of healthcare practitioners experienced in the treatment of cancer
  • Infections
  • Infusion-related reactions
  • Fertility
  • Pregnant and breast-feeding women
  • Elderly
  • Serious embolic events in combination with gemcitabine and cisplatin 
  • Driving and operating machinery
  • Hepatic/biliary/pancreatic
  • Monitor AST, ALT, bilirubin, renal, and thyroid function prior to and as indicated based on clinical evaluation

For more information:

Please consult the IMFINZI Product Monograph at https://imfinzi-en.azpm.ca for important information relating to adverse reactions, drug interactions, and dosing, which have not been discussed in this piece.

The Product Monograph is also available by calling us at 1-800-668-6000.

Back to top